1-Methylpiperazine → HCID 90313403, compound

HRID 1523769Notes

Reaction equation

HRID 1523769 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=1[S:19](Cl)(=[O:21])=[O:20]>>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][C:10]=1[S:19]([N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)(=[O:21])=[O:20]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 27786132-Bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride

Product 1

HCID 90313403HCID 90313403, compound

Procedure

The title compound was prepared in a manner similar to that described for Intermediate EU using 1-methylpiperazine and 2-bromo-5-(trifluoromethyl)benzene-1-sulfonyl chloride. 1H NMR (500 MHz, CDCl3) δ 8.37-8.28 (d, J=2.2, 1H), 7.98-7.86 (d, J=8.2, 1H), 7.73-7.59 (d, J=8.2, 1H), 3.45-3.31 (t, J=5.0, 4H), 2.60-2.42 (t, J=4.9, 4H), 2.40-2.20 (d, J=1.5, 3H).

Sources & evidence

ORD record
ord-19fdee3ccee74504a5ed41c8fd0f75a1
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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