反应详情

A mixture of 2-bromobenzenethiol (6 g, 30 mmol), ethyl 3-chloropropanoate (13 g, 96 mmol), K2CO3 (8.8 g, 64 mmol) and acetone (150 mL) was refluxed for 15 h. The reaction mixture was filtered and the filter cake washed with acetone (50 mL). The filtrate was concentrated to dryness and subjected to FCC to give ethyl 3-(2-bromophenylthio)propanoate (7 g, 78%). MS (ESI): mass calcd. for C11H13O2S, 287.98; m/z found, 288.8 [M+H]+.

1. temperaturewas refluxed for 15 h
2. filtrationThe reaction mixture was filtered
3. washthe filter cake washed with acetone (50 mL)
4. concentrationThe filtrate was concentrated to dryness