(S)-tert-butyl 3-(2-bromo-N-methylphenylsulfonamido)-piperidine-1-carboxylate → 4'-(2-Aminopyrimidin-5-yl)-3'-fluoro-N-methyl-N-[(3S)-piperidin-3-yl]biphenyl-2-sulfonamide

Participants

Reaction Steps

The title compound was prepared using methods analogous to those described in Example 376 using 5-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidin-2-amine and (S)-tert-butyl 3-(2-bromo-N-methylphenylsulfonamido)-piperidine-1-carboxylate yielding 41 mg (48%) of the title compound after HPLC purification. MS (ESI): mass calcd. for C27H32FN5O4S, 541.21; m/z found, 542.1 [M+H]+.

Provenance & Evidence