2-Amino-5-bromopyrimidine → 5-(4-Bromo-2,3-difluorophenyl)pyrimidin-2-amine

HRID 1523968Notes

Reaction equation

HRID 1523968 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[C:4]([F:11])[C:3]=1[F:12].Br[C:14]1[CH:15]=[N:16][C:17]([NH2:20])=[N:18][CH:19]=1>ClC1C=CC(C2N=CC(N)=NC=2)=C(F)C=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:14]2[CH:15]=[N:16][C:17]([NH2:20])=[N:18][CH:19]=2)=[C:4]([F:11])[C:3]=1[F:12]

Participants

4

Reactant 2

HCID 2313102-Amino-5-bromopyrimidineHCID 27732924-Bromo-2,3-difluorobenzeneboronic acid

Product 1

HCID 903142545-(4-Bromo-2,3-difluorophenyl)pyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 802004855-(4-Chloro-2-fluorophenyl)pyrazin-2-amineSolvent

Procedure

The title compound was prepared using analogous conditions to those described in 5-(4-chloro-2-fluorophenyl)pyrazin-2-amine using (4-bromo-2,3-difluorophenyl)boronic acid and 5-bromopyrimidin-2-amine. MS (ESI): mass calcd. for C10H6BrF2N3, 284.97; m/z found, 286.0 [M+H]+.

Sources & evidence

ORD record
ord-994f2e239f1149258e1951bfe6ef41df
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

Loading…