Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)- → HCID 90313766, compound

HRID 1524042Notes

Reaction equation

HRID 1524042 reaction equation
[C:1]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1B(O)O)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:19]1[CH:24]=[CH:23][C:22]([C:25](=[O:27])[CH3:26])=[C:21]([F:28])[CH:20]=1>>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([C:10]2[C:9]([S:6]([NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])(=[O:8])=[O:7])=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:20][C:21]=1[F:28])(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 4997616Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)-HCID 219385811-(4-Bromo-2-fluorophenyl)ethan-1-one

Product 1

HCID 90313766HCID 90313766, compound

Procedure

The title compound was prepared using conditions analogous to those described in Example 1 using (2-(N-(tert-butyl)sulfamoyl)phenyl)boronic acid and 1-(4-bromo-2-fluorophenyl)ethanone. 1H NMR (500 MHz, CDCl3) δ 8.19 (dd, J=7.9, 1.3, 1H), 7.95 (m, 1H), 7.63-7.57 (m, 1H), 7.57-7.52 (m, 1H), 7.38-7.30 (m, 2H), 7.28 (dd, J=7.5, 1.3, 1H), 2.70 (d, J=4.9, 3H), 1.05 (m, 9H).

Sources & evidence

ORD record
ord-b31e70f2708645c7810ad6a555a85169
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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