Tetrahydro-4H-pyran-4-ol → HCID 61373381, compound

HRID 1524088Notes

Reaction equation

HRID 1524088 reaction equation
[Br:1][C:2]1[C:3]([O:8][CH:9]2[CH2:14][CH2:13]S(=O)(=O)[CH2:11][CH2:10]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[O:17]1CCC(O)CC1>>[Br:1][C:2]1[C:3]([O:8][CH:9]2[CH2:14][CH2:13][O:17][CH2:11][CH2:10]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 90314095HCID 90314095, compound

Product 1

HCID 61373381HCID 61373381, compound

Procedure

The title compound was prepared in a manner similar to that described in Step A for the synthesis of 4-((3-bromopyridin-2-yl)oxy)tetrahydro-2H-thiopyran 1,1-dioxide using tetrahydro-2H-pyran-4-ol. 1H NMR (400 MHz, DMSO-d6) δ 8.11 (dd, J=4.8, 1.7, 1H), 7.99 (dd, J=7.7, 1.7, 1H), 6.90 (dd, J=7.7, 4.8, 1H), 5.22 (m, 1H), 3.86-3.77 (m, 2H), 3.49 (m, 2H), 1.95 (m, 2H), 1.61 (m, 2H).

Sources & evidence

ORD record
ord-e95e0b685c204776bee72deaf35b4469
Source dataset
uspto-grants-2015_07
Patent number
US09079866B2

Reaction notes

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