反应详情

A microwave vial was charged with 1-(chloroacetyl)-indoline (compound 47; 390 mg, 2.00 mmol), hydroxymethylmorpholine (compound 54; 280 mg, 2.39 mmol), triethylamine (0.55 ml, 4.00 mmol) and acetonitrile (2 ml). The vial was sealed and irradiated for 30 min at 100° C. The crude mixture was purified by flash column chromatography (silica, DCM/MeOH 1:0 to 92:8). The product was obtained as a white solid (435 mg; yield 79%).

1. customThe vial was sealed
2. customirradiated for 30 min at 100° C
3. customThe crude mixture was purified by flash column chromatography (silica, DCM/MeOH 1:0 to 92:8)
4. customThe product was obtained as a white solid (435 mg; yield 79%)