Maleimide → 3-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione

HRID 1524250ノート

反応式

HRID 1524250 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11]1(=[O:17])[NH:15][C:14](=[O:16])[CH:13]=[CH:12]1>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:13]1[CH2:12][C:11](=[O:17])[NH:15][C:14]1=[O:16]

参加物

4

反応物 2

HCID 10935MaleimideHCID 119785-Methylindole

生成物 1

HCID 670364713-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione収率 40.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

5-Methyl indole (10 g, 76 mmol) and maleimide (7.4 g, 76 mmol) in 77 mL of glacial acetic acid was heated at 90° C. for 24 h. The reaction mixture was cooled to RT, and the acetic acid was evaporated under reduced pressure. The residue was suspended in diethyl ether and filtered to obtain solid product (7 g).

後処理

  1. customthe acetic acid was evaporated under reduced pressure
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-95faf5e1039043699af36e4b9bef83fc
出典データセット
uspto-grants-2015_07
特許番号
US09079904B2

反応ノート

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