Diethyl Ether → HCID 67279648, compound

HRID 1524336Notes

Reaction equation

HRID 1524336 reaction equation
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]3[CH2:11][N:12]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:13][CH2:14][O:15][C:16]=3[N:17]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(OCC)C.[C:30]([N:34]=[C:35]=[O:36])([CH3:33])([CH3:32])[CH3:31]>C1COCC1>[C:30]([NH:34][C:35]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[CH:8]=[CH:9][C:10]3[CH2:11][N:12]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:13][CH2:14][O:15][C:16]=3[N:17]=2)[CH2:2][CH2:3]1)=[O:36])([CH3:33])([CH3:32])[CH3:31]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 62412tert-Butyl isocyanateHCID 67279638HCID 67279638, compound

Product 1

HCID 67279648HCID 67279648, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the compound (0.10 g) obtained in Example 33, step 1 in THF (3 mL)/diethyl ether (3 mL) was added tert-butyl isocyanate (41 μL), and the mixture was stirred at room temperature for 16 hr. The solvent was evaporated under reduced pressure, and the obtained solid was washed with diethyl ether/hexane to give tert-butyl 8-{4-[(tert-butylamino)carbonyl]piperazin-1-yl}-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate (0.11 g, 85%) as a white powder.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe obtained solid was washed with diethyl ether/hexane

Sources & evidence

ORD record
ord-0cc360692ecf43f0ba41cc902316d1ce
Source dataset
uspto-grants-2015_07
Patent number
US09079907B2

Reaction notes

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