Potassium Carbonate → HCID 57520339, compound

HRID 1524342Notes

Reaction equation

HRID 1524342 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([N:14]1[CH:18]=[C:17]([C:19]2[C:27]3[CH:26]=[N:25][CH:24]=[N:23][C:22]=3[N:21](C(OC(C)(C)C)=O)[CH:20]=2)[N:16]=[N:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CO>[CH2:7]([N:14]1[CH:18]=[C:17]([C:19]2[C:27]3[CH:26]=[N:25][CH:24]=[N:23][C:22]=3[NH:21][CH:20]=2)[N:16]=[N:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 70373666HCID 70373666, compound

Product 1

HCID 57520339HCID 57520339, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

17 mg (0.13 mmol) of potassium carbonate were added to a solution of 13 mg (0.035 mmol) of tert-butyl 5-(1-benzyl-1H-1,2,3-triazol-4-yl)pyrrolo[2,3-d]pyrimidine-7-carboxylate in 10 ml of methanol, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was evaporated, and the residue was purified by preparative HPLC, giving 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine as colourless solid; HPLC/MS: 1.48 min, [M+H] 277;

Workup

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-43f74b1a312346a4a2be0983c11f107d
Source dataset
uspto-grants-2015_07
Patent number
US09079910B2

Reaction notes

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