Sodium ethoxide → HCID 58046069, compound

HRID 1524460Notes

Reaction equation

HRID 1524460 reaction equation
Cl[C:2]1[C:3]([CH3:12])=[CH:4][C:5]2[N:6]([C:8]([NH2:11])=[N:9][N:10]=2)[N:7]=1.[O-:13][CH2:14][CH3:15].[Na+]>C(O)C>[CH2:14]([O:13][C:2]1[C:3]([CH3:12])=[CH:4][C:5]2[N:6]([C:8]([NH2:11])=[N:9][N:10]=2)[N:7]=1)[CH3:15]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 58045884HCID 58045884, compound

Product 1

HCID 58046069HCID 58046069, compoundYield 45.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

6-Chloro-7-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W2.005; 1 g) was dissolved in ethanol (50 ml), admixed under argon with sodium ethoxide (2.2 g) and stirred at 60° C. for 1 h. Then the mixture was dried and the residue was purified using a 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 40 min). The clean product fractions were combined and dried. 480 mg of the title compound were obtained.

Workup

  1. customThen the mixture was dried
  2. customthe residue was purified
  3. customa 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 40 min)
  4. customdried

Sources & evidence

ORD record
ord-c5cc6d38be634ee9b21c5d583777826d
Source dataset
uspto-grants-2015_07
Patent number
US09079906B2

Reaction notes

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