Sodium ethoxide → HCID 58046058, compound

HRID 1524478Notes

Reaction equation

HRID 1524478 reaction equation
Br.Cl[C:3]1[C:4]2[CH2:15][CH2:14][CH2:13][C:5]=2[C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1.[O-:16][CH2:17][CH3:18].[Na+]>C(O)C>[CH2:17]([O:16][C:3]1[C:4]2[CH2:15][CH2:14][CH2:13][C:5]=2[C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1)[CH3:18]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 86650799HCID 86650799, compound

Product 1

HCID 58046058HCID 58046058, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-Chloro-8,9-dihydro-7H-cyclopenta[d][1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.017, 1.0 g) was dissolved in ethanol (50 ml) while stirring and under argon. Thereafter, the reaction mixture was admixed with sodium ethoxide (1.41 g) and stirred at 60° C. for 1 h. After the solvent had been drawn off, the residue was purified using a 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 60 min). The clean product fractions were combined and dried. 662 mg of the title compound were obtained.

Workup

  1. stirringstirred at 60° C. for 1 h
  2. customthe residue was purified
  3. customa 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 60 min)
  4. customdried

Sources & evidence

ORD record
ord-5093919b7e994b8c86ad7eb1906b0985
Source dataset
uspto-grants-2015_07
Patent number
US09079906B2

Reaction notes

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