反应详情

温度

85 °C

6,8-Diethoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W1.126; 80 mg, 0.358 mmol) was dissolved in isopropanol (10 ml), and sodium isopropoxide (297 mg) was added. The mixture was heated to 85° C. for 1 h and concentrated, the residue was dissolved in water and a pH of 6 was established by adding aqueous hydrochloric acid. The mixture was extracted with ethyl acetate and the combined organic phases were dried and concentrated. The remaining residue was purified by flash chromatography (dichloromethane:MeOH). Yield: 58 mg.

1. concentrationconcentrated
2. dissolutionthe residue was dissolved in water
3. additionby adding aqueous hydrochloric acid
4. extractionThe mixture was extracted with ethyl acetate
5. customthe combined organic phases were dried
6. concentrationconcentrated
7. customThe remaining residue was purified by flash chromatography (dichloromethane:MeOH)