Hydrazine hydrate (1:1) → (6-Chloro-4-methanesulfonylpyridazin-3-yl)hydrazine

HRID 1524514Notes

Reaction equation

HRID 1524514 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([Cl:12])=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].O.[NH2:14][NH2:15]>O1CCOCC1>[Cl:12][C:5]1[N:4]=[N:3][C:2]([NH:14][NH2:15])=[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 580457893,6-Dichloro-4-methanesulfonylpyridazine

Product 1

HCID 58045948(6-Chloro-4-methanesulfonylpyridazin-3-yl)hydrazine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3,6-Dichloro-4-methanesulfonylpyridazine (W4.126; 660 mg, 2.9 mmol) was dissolved in 1,4-dioxane (5 ml) and hydrazine hydrate (295 μl, 5.8 mmol) was added. The mixture was stirred at RT for 4 h, then concentrated, and the residue was purified by flash chromatography (dichloromethane:ethyl acetate). Yield: 200 mg

Workup

  1. concentrationconcentrated
  2. customthe residue was purified by flash chromatography (dichloromethane:ethyl acetate)

Sources & evidence

ORD record
ord-890f94d0c327430bbe25bd6e4d8fd4f3
Source dataset
uspto-grants-2015_07
Patent number
US09079906B2

Reaction notes

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