HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1524619Generated: November 4, 2026
4-Toluenesulfonyl chloride → (S)-2-(2,2,4-trimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzene sulfonate
https://huagongshe.com/reaction/1524619
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol | HCID 11062680 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-2-(2,2,4-trimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzene sulfonate | HCID 13343712 | — |
Reaction Steps
To a solution of compound 4 and Et3N in DCM was added TsCl dropwise. The resulting mixture was stirred at 0° C. for 30 min. The solid was filtered and the solvent was removed. The residue was purified by column chromatography to give compound 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09079913B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-eb11d254e5734bd2814ad87c9eff6fd2 |
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| Source note | uspto-grants-2015_07 |
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