Dimethylmethylenammonium chloride → 2-[(Dimethylamino)methyl]furo[2,3-c]isoquinolin-5(4H)-one hydrochloride

HRID 1524628ノート

反応式

HRID 1524628 の反応式
[CH:1]1[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[C:6](=[O:14])[NH:5][C:4]=2[O:3][CH:2]=1.[Cl-:15].[CH3:16][N+:17](=[CH2:19])[CH3:18]>CN(C)C=O.C(#N)C>[ClH:15].[CH3:16][N:17]([CH2:19][C:2]1[O:3][C:4]2[NH:5][C:6](=[O:14])[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:13]=2[CH:1]=1)[CH3:18]

参加物

5

反応物 2

HCID 11051579Dimethylmethylenammonium chlorideHCID 58024727Furo[2,3-c]isoquinolin-5(4H)-one

生成物 1

HCID 446009722-[(Dimethylamino)methyl]furo[2,3-c]isoquinolin-5(4H)-one hydrochloride収率 65%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6342Acetonitrile溶媒

実験手順

Furo[2,3-c]isoquinolin-5(4H)-one (55 mg, 0.27 mmol) was dissolved in a mixture of dry dimethylformamide (1 ml) and dry acetonitrile (2 ml) and treated with N,N-dimethyl(methylene)ammonium chloride (1 mmol) prepared according to known procedure (Kinast G. et al. Angew. Chem. Int. Ed. Engl. 1976, 15(4), 239-240; Bohme H. et al. Chem. Ber. 1960, 93, 1305). The reaction mixture was refluxed overnight, and the resulting precipitate was filtered and washed with dry diethyl ether to give the title compound. Yield: 65%.

後処理

  1. customprepared
  2. temperatureThe reaction mixture was refluxed overnight
  3. filtrationthe resulting precipitate was filtered
  4. washwashed with dry diethyl ether

出典と根拠

ORDレコード
ord-e9e2e5833a774735a2a63bc5b6fa1be9
出典データセット
uspto-grants-2015_07
特許番号
US09079915B2

反応ノート

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