HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1524632Generated: November 3, 2026
Cesium carbonate → Methyl 5-fluoromethoxypyridine-2-carboxylate
https://huagongshe.com/reaction/1524632
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Methyl 5-hydroxypyridine-2-carboxylate | HCID 4715126 | — |
| Reactant | Fluoromethyl 4-methylbenzenesulfonate | HCID 13862289 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 5-fluoromethoxypyridine-2-carboxylate | HCID 57827265 | — |
Reaction Steps
A solution containing fluoromethyl toluene-4-sulfonate (233 mg) in DMF was added to a solution containing methyl 5-hydroxypyridine-2-carboxylate (100 mg) and cesium carbonate (532 mg) in DMF (5 mL). The reaction solution was stirred at 70° C. for 3 h. The reaction solution was cooled to RT. EtOAc and saturated aqueous NH4Cl were added to the reaction solution, and the organic layer was separated. The organic layer was dried over anhydrous MgSO4, and the insoluble matter was separated by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09079914B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-ae65763f67ab4127a3d6c3b7e535a246 |
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| Source note | uspto-grants-2015_07 |
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