反应详情

温度

70 °C

A solution containing fluoromethyl toluene-4-sulfonate (233 mg) in DMF was added to a solution containing methyl 5-hydroxypyridine-2-carboxylate (100 mg) and cesium carbonate (532 mg) in DMF (5 mL). The reaction solution was stirred at 70° C. for 3 h. The reaction solution was cooled to RT. EtOAc and saturated aqueous NH4Cl were added to the reaction solution, and the organic layer was separated. The organic layer was dried over anhydrous MgSO4, and the insoluble matter was separated by filtration.

1. additionwas added to a solution
2. temperatureThe reaction solution was cooled to RT
3. customthe organic layer was separated
4. dry with materialThe organic layer was dried over anhydrous MgSO4
5. customthe insoluble matter was separated by filtration