反应详情

Methyl 5-(fluoromethyl)pyrazine-2-carboxylate (94 mg) was dissolved in dioxan (1 mL) and water (1 mL) was added, followed by lithium hydroxide monohydrate (60 mg). After stirring at RT for 18 h, diethyl ether (20 mL) was added and the mixture was then extracted with NaOH (1 N, aq., 2×20 mL). The aqueous portions were acidified with 6N HCl to pH 1, extracted with EtOAc (2×40 mL), the combined organic portions dried over MgSO4 and evaporated to afford the title compound as a white solid (71 mg).

1. extractionthe mixture was then extracted with NaOH (1 N, aq., 2×20 mL)
2. extractionextracted with EtOAc (2×40 mL)
3. dry with materialthe combined organic portions dried over MgSO4
4. customevaporated