HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → (s)-2-Phenyl-1-(5-phenyloxazol-2-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | (s)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-n-(2-oxo-2-phenyl-ethyl)-3-phenyl-propionamide | HCID 66674794 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (s)-2-Phenyl-1-(5-phenyloxazol-2-yl)ethanamine | HCID 42048374 | 90% |
Reaction Steps
A solution of the product from Example 48 Part B (160 mg, 0.4 mmol) in EtOH (10 mL) was added to hydrazine (39 mg, 1.2 mmol). The reaction mixture was refluxed for 2 h. It was cooled to rt. EtOH was removed under vacuum. The residue was re-dissolved in dichloromethane. The undissolved solid was removed by filtration. The filtrate was concentrated to yield 95 mg of the product as a yellow solid (90% yield). MS 265.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09079860B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-1fbc486fe9c2486ca8024229b616c280 |
| Source note | uspto-grants-2015_07 |