HCID 19379765, compound → HCID 19379797, compound

HRID 1525126Notes

Reaction equation

HRID 1525126 reaction equation
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([Cl:17])=[CH:12][CH:13]=2)[N:8]([CH:18]2[CH2:20][CH2:19]2)[CH:7]=1)=[O:5])C>Cl>[Cl:17][C:11]1[N:10]=[C:9]2[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]2[CH:18]2[CH2:20][CH2:19]2)=[CH:13][CH:12]=1

Participants

3

Reactant 1

HCID 19379765HCID 19379765, compound

Product 1

HCID 19379797HCID 19379797, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

A suspension of 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester (prepared according to EP 607825; 500 mg) in 6N HCl (6 ml) was stirred at 100° C. for 30 min. The reaction mixture was allowed to reach rt and the resulting crystals were collected by filtration and sequentially washed with water and MeOH, affording a beige solid.

Workup

  1. customto reach rt
  2. filtrationthe resulting crystals were collected by filtration
  3. washsequentially washed with water and MeOH
  4. customaffording a beige solid

Sources & evidence

ORD record
ord-dbc53be7b54b4f2180e63817f1aeab35
Source dataset
uspto-grants-2015_07
Patent number
US09079922B2

Reaction notes

Loading…