Sodium Iodide → HCID 86730904, compound

HRID 1525134Notes

Reaction equation

HRID 1525134 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][N:12]1[C:17]([O:19][CH2:20]Cl)=[O:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[I-:23].[Na+]>CC(C)=O>[CH3:1][O:2][C:3](=[O:22])[CH:4]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][N:12]1[C:17]([O:19][CH2:20][I:23])=[O:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 86730903HCID 86730903, compound

Product 1

HCID 86730904HCID 86730904, compoundYield 73.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 37 (0.28 g, 0.86 mmol) and sodium iodide (0.387 g, 2.58 mmol) in acetone (6 mL) was stirred overnight. The acetone was evaporated. The residue was dissolved in ethyl acetate (80 mL) and washed with saturated sodium bisulfate (30 mL) and brine (30 mL) and dried over anhydrous sodium sulfate. The solvent was evaporated and the residue was dried in vacuum to give 38 as a syrup (0.263 g) (yield, 73%).

Workup

  1. customThe acetone was evaporated
  2. dissolutionThe residue was dissolved in ethyl acetate (80 mL)
  3. washwashed with saturated sodium bisulfate (30 mL) and brine (30 mL)
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated
  6. customthe residue was dried in vacuum

Sources & evidence

ORD record
ord-ed1860d5bc0f4e858378c176af1d97c0
Source dataset
uspto-grants-2015_07
Patent number
US09079928B2

Reaction notes

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