Di-tert-butyl dicarbonate → HCID 89462302, compound

HRID 1525208Notes

Reaction equation

HRID 1525208 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[O:18](C(OC(C)(C)C)=O)[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=O>C(#N)C>[C:19]([N:8]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:18]

Participants

4

Reactant 2

HCID 90495Di-tert-butyl dicarbonateHCID 775227HCID 775227, compound

Product 1

HCID 89462302HCID 89462302, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a mixture of (4-bromophenyl)(4-methoxyphenyl)methylamine, 1-1-c, (2 g, 6.8 mmol) in acetonitrile (25 ml) was added BOC2O (1.5 equivalents) and stirred at room temperature for 24 h. The reaction mixture was evaporated to dryness and purified over silica gel (5% MeOH/DCM) to give N-Boc-(4-bromophenyl)(4-methoxyphenyl)methylamine.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. custompurified over silica gel (5% MeOH/DCM)

Sources & evidence

ORD record
ord-5a249f23109b4972a4201682c85924c2
Source dataset
uspto-grants-2015_07
Patent number
US09079930B2

Reaction notes

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