反应详情

A mixture of ethyl 3-(dimethylamino)-2-nitroacrylate, 35i-f, (1 g, 5.3 mmol) and pyridazine-3-carboximidamide (0.8 g, 5.3 mmol) in CH3OH (30 mL) was added with NaOCH3 (3.4 g, 6.36 mmol) and refluxed overnight. The pH of reaction mixture was adjusted to 7 by addition of concentrated HCl. The solids were filtered to afford the product, 35i-g, (1 g, 86%). 1H NMR (300 MHz, DMSO) δ 7.77 (dd, J=4.8, 7.5 Hz, 2H), 8.29 (d, J=8.4 Hz, 1H), 8.77 (s, 1H), 9.26 (d, J=4.5 Hz, 1H). LC-MS (M+H)+ 220.1

1. temperaturerefluxed overnight
2. customThe pH of reaction mixture
3. filtrationThe solids were filtered