Trifluoroacetic acid → HCID 178468721, compound

HRID 1525341Notes

Reaction equation

HRID 1525341 reaction equation
COC1C=CC(C[O:8][C:9]2[C:14]([C:15]3[O:19][N:18]=[C:17]([C:20]4[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][CH:21]=4)[CH:16]=3)=[CH:13][N:12]=[C:11]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[N:10]=2)=CC=1.F[C:39](F)(F)[C:40](O)=O>C(Cl)Cl>[OH:8][C:9]1[C:14]([C:15]2[O:19][N:18]=[C:17]([C:20]3[CH:29]=[CH:28][C:23]([C:24]([O:26][CH2:39][CH3:40])=[O:25])=[CH:22][CH:21]=3)[CH:16]=2)=[CH:13][N:12]=[C:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[N:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 89471307Methyl 4-(5-(4-(4-methoxybenzyloxy)-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)benzoate

Product 1

HCID 178468721HCID 178468721, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 37-k (300 mg, 0.61 mmol) in DCM (5 mL) was added trifluoroactic acid (2.5 mL) dropwise. The mixture was stirred overnight at room temperature. The reaction mixture was evaporated to dryness to give compound 37-m, which was used in the next step without further purification.

Workup

  1. customThe reaction mixture was evaporated to dryness

Sources & evidence

ORD record
ord-ad55741015f047a3b48493d9025e5071
Source dataset
uspto-grants-2015_07
Patent number
US09079930B2

Reaction notes

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