反应详情

温度

50 °C

To a solution of N-(3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)acetamide (526 mg, 2.12 mmol) in ethanol (16 mL) were added iodic acid (93 mg, 0.53 mmol) and iodine (294 mg, 1.16 mmol). The reaction was stirred for 18 h at 50° C. The reaction mixture was concentrated in vacuo and the residue was dissolved in CH2Cl2 and washed with a 2 N Na2SO3 solution. The organic phase was dried over MgSO4, filtered and evaporated to give N-(3-(2-chlorophenyl)-4-iodo-1-methyl-1H-pyrazol-5-yl)acetamide as a light orange solid (756 mg), which was used as such in the subsequent step.

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionthe residue was dissolved in CH2Cl2
3. washwashed with a 2 N Na2SO3 solution
4. dry with materialThe organic phase was dried over MgSO4
5. filtrationfiltered
6. customevaporated