HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1525629Generated: November 3, 2026
Ammonium formate → 4-amino-2,3-dihydro-1H-isoindol-1-one
https://huagongshe.com/reaction/1525629
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 4-nitro-2,3-dihydro-1H-isoindol-1-one | HCID 21961387 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-amino-2,3-dihydro-1H-isoindol-1-one | HCID 9855513 | 92% |
Reaction Steps
A mixture of 4-nitro-2,3-dihydro-1H-isoindol-1-one (20 g), ammonium formate (35 g) and 7.5% Pd/C (0.6 g) in methanol (60 ml) was stirred for 2 hours by heating up to 35° C. Pd/C was filtered and the filtrate concentrated under reduced pressure. The residue was recrystallized from water to give 15.3 g of light yellow solid. yield: 92%. mp: 195.6-197° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09085530B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-ace2a51603bc43feb12ac5b518b8ad47 |
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| Source note | uspto-grants-2015_07 |
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