反应详情

温度

35 °C

A mixture of 4-nitro-2,3-dihydro-1H-isoindol-1-one (20 g), ammonium formate (35 g) and 7.5% Pd/C (0.6 g) in methanol (60 ml) was stirred for 2 hours by heating up to 35° C. Pd/C was filtered and the filtrate concentrated under reduced pressure. The residue was recrystallized from water to give 15.3 g of light yellow solid. yield: 92%. mp: 195.6-197° C.

1. filtrationPd/C was filtered
2. concentrationthe filtrate concentrated under reduced pressure
3. customThe residue was recrystallized from water
4. customto give 15.3 g of light yellow solid