反应详情

To a solution of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzaldehyde (i.e. the product of example S.1, Step 1, 0.50 g) and lithium chloride (53 mg, 1.24 mmol, 1.00 equiv.) in THF (15 mL) was added a solution of methyl magnesium bromide (1.78 mL, 1.4 M in THF/toluene, 2.49 mmol, 2.00 equiv.) at −70° C.

1. customat −70° C.