Sodium Bicarbonate → HCID 67124168, compound

Participants

Reaction Steps

To a solution of 1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanol (i.e. the product of example S.2, Step 1, 160 mg, 0.38 mmol) in CH2Cl2 (10 mL) was added Dess-Martin-Periodinane (243 mg, 0.57 mmol, 1.5 equiv.) in small portions. The mixture was stirred at room temperature over night, then saturated aqueous NaHCO3-solution was added and the mixture was left at room temperature for 1 h. The layers were separated and the organic layer was washed with water, dried over Na2SO4 and evaporated in vacuum to give the title compound (120 mg, 75%), which was used in the next reaction without further purification.

Provenance & Evidence