反应详情

To a solution of 1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-ethanol (i.e. the product of example S.2, Step 1, 160 mg, 0.38 mmol) in CH2Cl2 (10 mL) was added Dess-Martin-Periodinane (243 mg, 0.57 mmol, 1.5 equiv.) in small portions. The mixture was stirred at room temperature over night, then saturated aqueous NaHCO3-solution was added and the mixture was left at room temperature for 1 h. The layers were separated and the organic layer was washed with water, dried over Na2SO4 and evaporated in vacuum to give the title compound (120 mg, 75%), which was used in the next reaction without further purification.

1. customThe layers were separated
2. washthe organic layer was washed with water
3. dry with materialdried over Na2SO4
4. customevaporated in vacuum