Sodium Hydroxide → HCID 86722740, compound

Participants

Reaction Steps

Compound 7 (3.9 g) was dissolved in tetrahydrofuran (55 mL). Lithium hydride aluminum (620 mg) was carefully added thereto and the reaction solution was refluexed with heating for 2 hours. After cooling the reaction solution to room temperature, 2N aqueous sodium hydroxide solution (3 mL) was added carefully, further tetrahydrofuran and anhydrous magnesium sulfate were added, followed by stirring for 1 hour. The reaction solution was filtered with Celite (brand name) and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1) to obtain the title compound (3.4 g) having the following physical property values.

Provenance & Evidence