反应详情

Compound 7 (3.9 g) was dissolved in tetrahydrofuran (55 mL). Lithium hydride aluminum (620 mg) was carefully added thereto and the reaction solution was refluexed with heating for 2 hours. After cooling the reaction solution to room temperature, 2N aqueous sodium hydroxide solution (3 mL) was added carefully, further tetrahydrofuran and anhydrous magnesium sulfate were added, followed by stirring for 1 hour. The reaction solution was filtered with Celite (brand name) and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1) to obtain the title compound (3.4 g) having the following physical property values.

1. temperaturewith heating for 2 hours
2. filtrationThe reaction solution was filtered with Celite (brand name)
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1)