反应详情

Bromoacetic acid (4.30 g) and N-hydroxysuccinimide (4.03 g) were dissolved in DCM (25 ml). The mixture was stirred on a magnetic stirrer at room temperature. DCC was added (7.42 g) in one portion and the mixture was reacted overnight. The reaction mixture was filtered to remove dicyclohexylurea. The filter cake was washed several times with DCM. The combined filtrates were washed three times with saturated aqueous sodium chloride solution (30 mL/each wash), dried over anhydrous magnesium sulfate, and filtered. The title compound was obtained as a white solid (5 g) after rotary evaporation in vacuo.

1. customthe mixture was reacted overnight
2. filtrationThe reaction mixture was filtered
3. customto remove dicyclohexylurea
4. washThe filter cake was washed several times with DCM
5. washThe combined filtrates were washed three times with saturated aqueous sodium chloride solution (30 mL/
6. washeach wash),
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationfiltered