反应详情

6-methyl-4-(pyrimidin-5-yloxy)picolinonitrile (4.31 g, 20.3 mmol, 1.00 eq) was dissolved in dioxane (90 mL), and 2N NaOH (45 mL) was added. The mixture was refluxed for 18 h and after cooling the reaction was neutralized with 2N HCl (45 mL). The water and solvent were removed in vacuo and the crude reaction was dissolved in 10% MeOH/CH2Cl2. The undissolved salt was filtered off and the solvents were removed in vacuo to afford 4.65 g (99%) of the title compound as a white solid which was used without further purification.

1. temperatureThe mixture was refluxed for 18 h
2. temperatureafter cooling the reaction
3. customThe water and solvent were removed in vacuo
4. customthe crude reaction
5. filtrationThe undissolved salt was filtered off
6. customthe solvents were removed in vacuo