Azobisisobutyronitrile → 2-Bromo-2-(4-bromo-2,6-difluorophenyl)ethyl acetate

Temperature

80 °C

A solution of 4-bromo-2,6-difluorophenethyl acetate (1.182 mmol) in carbon tetrachloride (3 mL) was degassed with a stream of nitrogen for 5 min and was then treated with N-bromosuccinimide (1.301 mmol) and azobisisobutyronitrile (0.118 mmol). The reaction vessel was purged with nitrogen and sealed, and the mixture was stirred in an oil bath at 80° C. overnight. The reaction was then cooled and was concentrated to dryness under a stream of nitrogen. The crude material was dissolved in ethyl acetate (50 mL) and was washed twice with water. The organic layer was then dried over sodium sulfate, filtered and concentrated in vacuo. The product was dissolved in dichloromethane and was again concentrated to dryness in vacuo to afford the title compound as a yellow oil (403 mg, 86% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 2.01 (s, 3 H) 4.55-4.70 (m, 2 H) 5.50 (t, J=7.45 Hz, 1 H) 7.55-7.67 (m, 2 H).

1. customThe reaction vessel was purged with nitrogen
2. customsealed
3. temperatureThe reaction was then cooled
4. concentrationwas concentrated to dryness under a stream of nitrogen
5. dissolutionThe crude material was dissolved in ethyl acetate (50 mL)
6. washwas washed twice with water
7. dry with materialThe organic layer was then dried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. dissolutionThe product was dissolved in dichloromethane
11. concentrationwas again concentrated to dryness in vacuo

ORD record

ord-3e2deb60105e444eb9980297f8b37f55

Source dataset

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09084794B2