反应详情

A solution of (R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride (646 mg, 2 mMol) in dichloromethane (80 ml) was shaken with a saturated solution of sodium hydrogen carbonate (20 ml) for 30 seconds. The organic layer was separated and the aqueous layer was extracted with dichloromethane (2×50 ml). The combined organic extracts were washed with water (50 ml) and brine (50 ml), dried (MgSO4). The solvent was evaporated giving the title compound which was used immediately.

1. customThe organic layer was separated
2. extractionthe aqueous layer was extracted with dichloromethane (2×50 ml)
3. washThe combined organic extracts were washed with water (50 ml) and brine (50 ml)
4. dry with materialdried (MgSO4)
5. customThe solvent was evaporated