Sodium Bicarbonate → HCID 53885254, compound

HRID 1526Notes

Reaction equation

HRID 1526 reaction equation
Cl.[CH2:2]([O:4][C:5]([C:7]1([C:20]([O:22][CH2:23][CH3:24])=[O:21])[O:11][C:10]2[CH:12]=[CH:13][C:14]([CH2:16][C@H:17]([NH2:19])[CH3:18])=[CH:15][C:9]=2[O:8]1)=[O:6])[CH3:3].C(=O)([O-])O.[Na+]>ClCCl>[NH2:19][C@H:17]([CH3:18])[CH2:16][C:14]1[CH:13]=[CH:12][C:10]2[O:11][C:7]([C:20]([O:22][CH2:23][CH3:24])=[O:21])([C:5]([O:4][CH2:2][CH3:3])=[O:6])[O:8][C:9]=2[CH:15]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 67642885(R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride

Product 1

HCID 53885254HCID 53885254, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride (646 mg, 2 mMol) in dichloromethane (80 ml) was shaken with a saturated solution of sodium hydrogen carbonate (20 ml) for 30 seconds. The organic layer was separated and the aqueous layer was extracted with dichloromethane (2×50 ml). The combined organic extracts were washed with water (50 ml) and brine (50 ml), dried (MgSO4). The solvent was evaporated giving the title compound which was used immediately.

Workup

  1. customThe organic layer was separated
  2. extractionthe aqueous layer was extracted with dichloromethane (2×50 ml)
  3. washThe combined organic extracts were washed with water (50 ml) and brine (50 ml)
  4. dry with materialdried (MgSO4)
  5. customThe solvent was evaporated

Sources & evidence

ORD record
ord-265f1fbbd21744dfa0e52587c35414e9
Source dataset
uspto-grants-1998_03
Patent number
US05726165

Reaction notes

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