Hydrochloric Acid → HCID 70874059, compound

HRID 1526127Notes

Reaction equation

HRID 1526127 reaction equation
O.O.[Sn](Cl)(Cl)(Cl)Cl.Cl.[C:9]([C:11]1[C:16](=[S:17])[NH:15][C:14]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[C:13]([C:26]([O:28]CC)=O)[C:12]=1[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[N+:37]([O-:39])=O)#[N:10].[CH2:40](O)C>>[OH:39][N:37]1[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[C:12]2[C:11]([C:9]#[N:10])=[C:16]([S:17][CH3:40])[N:15]=[C:14]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[C:13]=2[C:26]1=[O:28]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 70874350HCID 70874350, compoundHCID 85782573Tin tetrachloride dihydrate

Product 1

HCID 70874059HCID 70874059, compoundYield 80%

Procedure

12.05 g (53.4 mmol) of tin chloride dihydrate and 14 ml of concentrated hydrochloric acid are added to 4 g (8.9 mmol) of ethyl 5-cyano-2-(4-methoxyphenyl)-4-(2-nitrophenyl)-6-thioxo-1,6-dihydropyridine-3-carboxylate dissolved in 160 ml of ethanol. The reaction medium is carried at 65° C. for 4 hours. The precipitate obtained is filtered, rinsed with isopropanol and then dried to yield 2.78 g (80%) of 6-hydroxy-4-(4-methoxyphenyl)-2-(methylthio)-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-1-carbonitrile in the form of a yellow solid.

Workup

  1. customThe precipitate obtained
  2. filtrationis filtered
  3. washrinsed with isopropanol
  4. customdried

Sources & evidence

ORD record
ord-a334220ee51a4f07a353b89759812765
Source dataset
uspto-grants-2015_07
Patent number
US09085575B2

Reaction notes

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