HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1526162Generated: November 3, 2026
3-Nitrophenol → 3-Chloro-6-ethyl-5-(3-nitrophenoxy)pyrazine-2-carboxamide
https://huagongshe.com/reaction/1526162
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Nitrophenol | HCID 11137 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3,5-Dichloro-6-ethylpyrazine-2-carboxamide | HCID 84819960 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Chloro-6-ethyl-5-(3-nitrophenoxy)pyrazine-2-carboxamide | HCID 89709111 | 72.4% |
Reaction Steps
A mixture of 3-nitrophenol (1 g), 3,5-dichloro-6-ethylpyrazine-2-carboxamide (1.74 g), diisopropylethylamine (2.63 mL), and dioxane (10 mL) was stirred at 80° C. overnight. To the reaction mixture was added water, and the precipitated solid was collected by filtration and then dried under reduced pressure to obtain 3-chloro-6-ethyl-5-(3-nitrophenoxy)pyrazine-2-carboxamide (1.68 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09085540B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-e119e89e13394fa79a18b60105a740c0 |
|---|
| Source note | uspto-grants-2015_07 |
|---|
