Hydrogen chloride-ethyl acetate → HCID 117666986, compound

HRID 1526245Notes

Reaction equation

HRID 1526245 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]1[N:9]([CH3:10])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1.C(OC(=O)C)C.[ClH:24]>C(OCC)(=O)C>[ClH:24].[ClH:24].[CH3:1][O:2][CH2:3][C@H:4]1[CH2:5][NH:6][CH2:7][CH2:8][N:9]1[CH3:10]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 117675755HCID 117675755, compound

Product 1

HCID 117666986HCID 117666986, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of tert-butyl (3R)-3-(methoxymethyl)-4-methylpiperazine-1-carboxylate (220 mg) and ethyl acetate (2.33 mL) was added a 4 M hydrogen chloride ethyl acetate solution (2.19 mL), followed by stirring at room temperature overnight. The reactant was concentrated under reduced pressure to obtain (2R)-2-(methoxymethyl)-1-methylpiperazine dihydrochloride (218 mg) as a white solid.

Workup

  1. concentrationThe reactant was concentrated under reduced pressure

Sources & evidence

ORD record
ord-48fdf5a7748c44fe925fd8ba5c436787
Source dataset
uspto-grants-2015_07
Patent number
US09085540B2

Reaction notes

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