反应详情

温度

90 °C

To a mixture of 1-methyl-4-[1-(4-nitrophenyl)piperidin-4-yl]piperazine (4.84 g) and 1,2-dichloroethane (50 mL) was added 1-chloroethyl chloroformate (2.2 mL), followed by stirring at 90° C. for 3 hours. The solvent was evaporated under reduced pressure and then methanol (85 mL) was added thereto, followed by heating and refluxing for 1 hour. The solvent was evaporated under reduced pressure and the obtained residue was washed with ethyl acetate to obtain 1-[1-(4-nitrophenyl)piperidin-4-yl]piperazine monohydrochloride (3.74 g) as a yellow solid.

1. customThe solvent was evaporated under reduced pressure
2. additionmethanol (85 mL) was added
3. temperatureby heating
4. temperaturerefluxing for 1 hour
5. customThe solvent was evaporated under reduced pressure
6. washthe obtained residue was washed with ethyl acetate