Hydrazine hydrate (1:1) → HCID 117770456, compound

HRID 1526339Notes

Reaction equation

HRID 1526339 reaction equation
C(O[CH2:5][C:6]1[N:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])[C:8](=[O:15])[C:9]([C:13]#[N:14])=[C:10](Cl)[CH:11]=1)(=O)C.[OH2:23].[NH2:24][NH2:25]>C(O)C>[NH2:14][C:13]1[C:9]2[C:8](=[O:15])[N:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[C:6]([CH2:5][OH:23])=[CH:11][C:10]=2[NH:25][N:24]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 117770148HCID 117770148, compound

Product 1

HCID 117770456HCID 117770456, compoundYield 86.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (4-chloro-1-(2-chlorophenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)methyl acetate obtained in Step G (670 mg) in ethanol (3.97 mL) was added hydrazine monohydrate (398 mg) at room temperature. The reaction mixture was stirred at room temperature for 5 hr. The resulting solid was collected by filtration, washed with water, and dried under reduced pressure to give the title compound (500 mg).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-2afdf15e760847259cf730250126942f
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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