反应详情

温度

75 °C

A mixture of 4-chloro-1-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbaldehyde obtained in Step B (995 mg), hydroxylamine hydrochloride (516 mg) and sodium acetate (609 mg) in methanol/water (4:1, 12.4 mL) was heated at 75° C. for 2 hr, cooled to room temperature, and poured into ice water. The resulting solid was collected by filtration, washed with water, and dried under reduced pressure to give the title compound (968 mg).

1. temperaturecooled to room temperature
2. filtrationThe resulting solid was collected by filtration
3. washwashed with water
4. customdried under reduced pressure