反应详情

温度

90 °C

To a solution of 4-chloro-1-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile obtained in Step D (891 mg) in ethanol (6.72 mL) was added hydrazine monohydrate (252 mg) at room temperature. The reaction mixture was heated at 90° C. for 5 hr, and cooled to room temperature. The reaction mixture was concentrated under reduced pressure, to the residue was added water, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (854 mg).

1. temperaturecooled to room temperature
2. concentrationThe reaction mixture was concentrated under reduced pressure, to the residue
3. additionwas added water
4. extractionthe mixture was extracted with ethyl acetate
5. dry with materialThe extract was dried over anhydrous sodium sulfate
6. customthe solvent was evaporated under reduced pressure