反应详情

温度

70 °C

To a solution of 5-bromo-4-chloro-1-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile obtained in Step A (20.9 g) in ethanol (122 mL) was added hydrazine monohydrate (6.08 g) at room temperature. The reaction mixture was heated at 70° C. for 2 hr. The reaction mixture was cooled to room temperature, and poured into water. The resulting solid was collected by filtration, and washed with water to give the title compound (16.9 g).

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationThe resulting solid was collected by filtration
3. washwashed with water