Methanol → HCID 117770254, compound

HRID 1526360Notes

Reaction equation

HRID 1526360 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[C:4](=[O:17])[C:3]=1[CH:18]=O.Cl.[NH2:21][OH:22].C([O-])(=O)C.[Na+].CO>O>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]([C:8]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[C:4](=[O:17])[C:3]=1[CH:18]=[N:21][OH:22]

Participants

6

Reactant 4

HCID 887MethanolHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 117770750HCID 117770750, compound

Product 1

HCID 117770254HCID 117770254, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-(4-chloro-3-formyl-2-oxopyridin-1(2H)-yl)-3-fluorobenzonitrile obtained in Step C (2.70 g), hydroxylamine hydrochloride (814 mg), sodium acetate (1.60 g) and methanol (60 mL)/water (15 mL) was stirred at room temperature for 1 hr. The reaction solution was poured into ice water. The resulting solid was collected by filtration, and washed successively with water, 2-propanol and diethyl ether to give the title compound (2.39 g).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed successively with water, 2-propanol and diethyl ether

Sources & evidence

ORD record
ord-5dd05002353945e58e6d3002f2d77933
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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