HCID 89775215, compound → HCID 117770487, compound

HRID 1526374Notes

Reaction equation

HRID 1526374 reaction equation
[NH2:1][C:2]1[C:6]2[C:7](=[O:17])[N:8]([CH:12]([CH:14]3[CH2:16][CH2:15]3)[CH3:13])[CH:9]=[C:10]([Br:11])[C:5]=2[NH:4][N:3]=1>CCCCCC.C(O)C>[NH2:1][C:2]1[C:6]2[C:7](=[O:17])[N:8]([C@H:12]([CH:14]3[CH2:15][CH2:16]3)[CH3:13])[CH:9]=[C:10]([Br:11])[C:5]=2[NH:4][N:3]=1

Participants

3

Reactant 1

HCID 89775215HCID 89775215, compound

Product 1

HCID 117770487HCID 117770487, compoundYield 48.5%

Reagents, catalysts & solvents 1

HCID 21879635Ethanol hexaneSolvent

Procedure

Racemic 3-amino-7-bromo-5-(1-cyclopropylethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one obtained in Example 164 (1.1 g) was resolved by HPLC (column: CHIRALPAD AD, 50 mmID×500 mmL, manufactured by Daicel Chemical Industries, mobile phase: hexane/ethanol=800/200(v/v)) to give the title compound (533 mg) having a shorter retention time.

Sources & evidence

ORD record
ord-ed1bd9d7a953409cb91c9bf769777921
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

Loading…