Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid | HCID 53362086 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 53378645 | HCID 53378645 | — |
Reaction Steps
(R)-2-(9-Chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid (15 mg, 0.031 mmol) was dissolved in a suitable solvent (THF or acetone, 0.5 mL) and heated to 60° C. 2.08 M aqueous KOH (15 mL, 0.031 mmol) was added and the reaction mixture was cooled to 35° C. and stirred for 24 h. No solid product was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09085581B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-ee460ae04e7d4ca79d23a2cc524dea8b |
|---|
| Source note | uspto-grants-2015_07 |
|---|
