Hydrochloric Acid → Hydrochloric Acid

HRID 1526484Notes

Reaction equation

HRID 1526484 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[C:18]([OH:20])[N:17]=[C:16]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>O1CCOCC1>[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:15]=[C:16]([N:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[N:17]=[C:18]([OH:20])[CH:19]=2)[CH2:10][CH2:9]1.[ClH:27]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178451770HCID 178451770, compound

Product 2

HCID 313Hydrochloric AcidYield 82%HCID 1785156812-piperidin-1-yl-6-piperidin-4-yl-1H-pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of 4-(6-hydroxy-2-piperidin-1-yl-pyrimidin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester (0.05 mol) in 15% HCl in dioxane (100 mL) was stirred at reflux for 2 hours. After reaction was completed the mixture was cooled, precipitate was filtered, washed with dry ether and dried to obtain 6-Piperidin-4-yl-2-piperidin-1-yl-pyrimidin-4-ol as hydrochloride (12 g, 82%).

Workup

  1. temperatureat reflux for 2 hours
  2. customAfter reaction
  3. temperaturewas cooled
  4. filtrationprecipitate was filtered
  5. washwashed with dry ether
  6. customdried

Sources & evidence

ORD record
ord-2d57311fa1a64552b28f7bac66e41b49
Source dataset
uspto-grants-2015_07
Patent number
US09085585B2

Reaction notes

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