Hydrochloric Acid → Icotinib hydrochloride

HRID 1526522Notes

Reaction equation

HRID 1526522 reaction equation
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>CO>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 22024915Icotinib

Product 1

HCID 44609731Icotinib hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Icotinib (700 mg) and methanol (40 mL) were added into 100 mL of reaction flask, hydrogen chloride gas or concentrated hydrochloric acid was added while stirring. After its completion, the reaction mixture was filtrated to give crude products of Icotinib hydrochloride, which was then purified by recrystallization with isopropanol to give Icotinib hydrochloride (760 mg).

Workup

  1. additionwas added
  2. filtrationAfter its completion, the reaction mixture was filtrated

Sources & evidence

ORD record
ord-fff8d148ae044b9fbaad1d3724758ee0
Source dataset
uspto-grants-2015_07
Patent number
US09085588B2

Reaction notes

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